histaminebinding
Histamine binding refers to the interaction of the biogenic amine histamine with specific binding sites in the body, including histamine receptors and various histamine-binding proteins. This interaction initiates signaling pathways that regulate diverse physiological processes and can be targeted pharmacologically to treat conditions involving histamine.
The principal binding sites are the histamine receptors H1, H2, H3 and H4. These receptors are G
Binding affinity and kinetics determine the strength and duration of signaling. Agonists mimic histamine, while antagonists
In addition to receptor binding, histamine can be bound by non-receptor proteins that regulate its availability.
Clinically, aberrant histamine binding underlies allergic symptoms, gastric disorders, and certain neuroimmune processes. Understanding histamine binding