hemepocket
The hemepocket is a structural motif found in many proteins that bind heme, an iron-containing porphyrin ring. This pocket is a specialized cavity within a protein’s tertiary or quaternary structure that accommodates the heme group, positioning it precisely for optimal function. Hemepockets are critical in proteins involved in electron transfer, oxygen transport, and catalysis, such as cytochromes, hemoglobin, and peroxidases.
The architecture of a hemepocket varies depending on the protein’s role but typically involves hydrophobic residues
Mutations or modifications to the hemepocket can alter a protein’s function, sometimes leading to diseases or
Structural studies, including X-ray crystallography and NMR spectroscopy, have provided detailed insights into hemepocket configurations across