gp130based
gp130based refers to a family of receptor complexes that play a crucial role in cell signaling. The common component is the glycoprotein 130 (gp130) molecule, a transmembrane protein that acts as a signal transducer. This receptor is activated by a variety of cytokines, including interleukins (IL-6, IL-11, IL-27, IL-31) and oncostatin M (OSM). These cytokines are often referred to as IL-6 family cytokines due to their shared reliance on gp130 for signal transduction.
When a specific cytokine binds to its cognate receptor, it induces the recruitment of gp130 to the
The gp130-based receptor system is involved in a wide range of physiological processes. These include immune