gp130based

gp130based refers to a family of receptor complexes that play a crucial role in cell signaling. The common component is the glycoprotein 130 (gp130) molecule, a transmembrane protein that acts as a signal transducer. This receptor is activated by a variety of cytokines, including interleukins (IL-6, IL-11, IL-27, IL-31) and oncostatin M (OSM). These cytokines are often referred to as IL-6 family cytokines due to their shared reliance on gp130 for signal transduction.

When a specific cytokine binds to its cognate receptor, it induces the recruitment of gp130 to the complex. This binding event leads to the dimerization and activation of intracellular Janus kinases (JAKs). The activated JAKs then phosphorylate downstream signaling molecules, most notably STAT (Signal Transducer and Activator of Transcription) proteins. This JAK-STAT pathway is a primary mechanism by which gp130-based signaling exerts its effects.

The gp130-based receptor system is involved in a wide range of physiological processes. These include immune responses, inflammation, hematopoiesis (the formation of blood cellular components), cell proliferation, differentiation, and survival. Dysregulation of gp130-based signaling has been implicated in various diseases, such as inflammatory disorders, autoimmune diseases, cancer, and cardiovascular conditions. Consequently, understanding the intricacies of gp130-based signaling is vital for developing targeted therapeutic strategies.