glycinergiske
Glycinergic, or glycinergic signaling, refers to neurons and synapses in which glycine is the primary inhibitory neurotransmitter of the central nervous system. In glycinergic synapses, glycine is released from presynaptic terminals and binds to postsynaptic glycine receptors, opening chloride channels and producing hyperpolarization that reduces neuronal excitability.
The main receptor mediating glycinergic inhibition is the glycine receptor (GlyR), a pentameric ligand-gated chloride channel.
Glycinergic transmission relies on the recycling of glycine by transporter proteins. GlyT2 (neuronal) is primarily responsible
Clinical significance includes hyperekplexia (startle disease), caused by mutations in GLRA1 or GLRB, and sometimes SLC6A5
Glycinergic mechanisms also intersect with excitatory signaling, as glycine can act as a co-agonist at NMDA