fluconasool
Fluconazole, known as fluconasool in some regions, is an antifungal in the azole class. It is used to treat and prevent infections caused by susceptible yeasts. Fluconazole inhibits fungal 14-alpha-demethylase, reducing ergosterol synthesis and disrupting the cell membrane.
It is active mainly against Candida species (including C. albicans) and Cryptococcus neoformans. It has limited
Indications include oropharyngeal/esophageal candidiasis, vaginal candidiasis, and maintenance therapy for cryptococcal meningitis. It is also used
Pharmacokinetics: fluconazole has high oral bioavailability and good tissue penetration, including CSF when meninges are inflamed.
Safety and interactions: common adverse effects include nausea, abdominal pain, and headache. Rare but serious liver