fibrinoogeeni

Fibrinogen, also known as factor I, is a globular protein found in vertebrates that circulates in the blood plasma. It is a glycoprotein that is synthesized in the liver. Fibrinogen plays a crucial role in hemostasis, the process by which bleeding is stopped.

When a blood vessel is injured, fibrinogen is converted into fibrin by the enzyme thrombin. Fibrin molecules then polymerize to form a mesh-like network that traps blood cells and platelets, forming a blood clot. This clot effectively seals the injured vessel and prevents further blood loss. Fibrinogen also plays a role in wound healing and inflammatory responses.

The concentration of fibrinogen in the blood is an indicator of inflammation and tissue damage. Elevated levels of fibrinogen can be associated with increased risk of cardiovascular diseases, such as heart attack and stroke. Conversely, low levels of fibrinogen can lead to bleeding disorders.

The conversion of fibrinogen to fibrin is a complex process involving several clotting factors and enzymes. This cascade of reactions ensures that blood clots are formed only when and where they are needed, preventing inappropriate clotting within blood vessels. Genetic deficiencies in fibrinogen can result in conditions like afibrinogenemia or hypofibrinogenemia, which are characterized by severe bleeding tendencies.