erytropoese
Erythropoiesis is the process by which red blood cells (erythrocytes) are produced. In healthy adults, it occurs primarily in the red bone marrow of the axial skeleton and the ends of long bones; during fetal development the liver and spleen contribute significantly. The process begins with hematopoietic stem cells and proceeds through erythroid-committed progenitors to mature erythrocytes.
The erythroid lineage passes through a defined sequence of stages: proerythroblast, basophilic erythroblast, polychromatic erythroblast, and
Regulation of erythropoiesis is tightly controlled, predominantly by erythropoietin (EPO). EPO is produced mainly by kidney
Clinical relevance includes the maintenance of circulating red cell mass, with normal lifespan about 120 days