ephrinEphinteraktioner
Ephrin-Eph-interactions are a critical class of cell signaling mechanisms that play essential roles in various biological processes, including cell migration, axon guidance, vascular development, and immune responses. These interactions occur between Eph receptors, a family of receptor tyrosine kinases, and their corresponding ligands, ephrins, which are membrane-bound proteins. The Eph-ephrin system is categorized into two main groups: EphA receptors interact with ephrin-A ligands, while EphB receptors interact with ephrin-B ligands.
Ephrin ligands are divided into two classes based on their structural features: ephrin-A ligands are glycosylphosphatidylinositol
The Eph-ephrin system influences numerous developmental processes. During neural development, Eph-ephrin interactions guide the migration of
Dysregulation of Eph-ephrin interactions has been implicated in various diseases, including cancer, where altered signaling can