EphrinEphinteractions
EphrinEph interactions refer to a crucial class of cell-cell communication mediated by the Eph receptor tyrosine kinases and their corresponding ephrin ligands. These interactions are bidirectional, meaning that signals are transmitted both from the Eph-expressing cell to the ephrin-expressing cell (forward signaling) and vice-versa (reverse signaling). Ephrins are glycosylphosphatidylinositol (GPI)-anchored or transmembrane proteins, while Eph receptors are transmembrane tyrosine kinases.
The binding of an ephrin to its Eph receptor triggers intracellular signaling cascades within both the receptor-expressing
These interactions play vital roles in a wide range of developmental processes, including neural development, vascular