electrofilin2

Electrofilin2 is a protein encoded in humans by the *ELFN2* gene, located on chromosome 11 (11q24.1). It belongs to the electrofilin family, which comprises proteins involved in cellular signaling and cytoskeletal dynamics, particularly in neuronal cells. The electrofilin proteins are characterized by their ability to bind to actin filaments and regulate their organization, influencing processes such as cell migration, neurite outgrowth, and synaptic plasticity.

The primary function of electrofilin2 is thought to be the modulation of actin cytoskeleton remodeling. It interacts with actin filaments to promote their bundling or stabilization, which is critical for maintaining cellular structure and facilitating movement. Studies suggest that electrofilin2 plays a role in neuronal development, where proper actin dynamics are essential for the formation and function of synapses. Disruptions in electrofilin2 expression or function have been implicated in neurological disorders, though research in this area remains limited.

Electrofilin2 is expressed in various tissues, with notable levels found in the brain, particularly in regions associated with neural connectivity. Its expression is developmentally regulated, peaking during periods of active synaptogenesis. The protein’s activity is influenced by post-translational modifications, such as phosphorylation, which can alter its binding affinity to actin and thereby regulate its effects on cytoskeletal organization.

While electrofilin2’s precise physiological roles are still under investigation, its structural and functional similarities to other electrofilins suggest it may contribute to similar processes, including cell adhesion, migration, and signal transduction. Further research is needed to fully elucidate its specific mechanisms and potential involvement in disease pathways.