doripeenem

Doripenem is a carbapenem antibiotic used to treat serious bacterial infections. It is a broad-spectrum antibiotic effective against a wide range of Gram-positive and Gram-negative bacteria, including some that are resistant to other antibiotics. Doripenem works by inhibiting bacterial cell wall synthesis, leading to bacterial death.

It is typically administered intravenously and is often reserved for patients with complicated intra-abdominal infections, complicated urinary tract infections, and hospital-acquired pneumonia, including ventilator-associated pneumonia, when other treatment options are not suitable. Doripenem is not effective against viral or fungal infections.

The development of antibiotic resistance is a significant concern, and doripenem should be used judiciously to preserve its effectiveness. Potential side effects of doripenem include nausea, vomiting, diarrhea, headache, and rash. More serious side effects, though rare, can include allergic reactions, seizures, and Clostridium difficile-associated diarrhea.

Doripenem is a synthetic carbapenem that differs structurally from other carbapenems, which may contribute to its spectrum of activity and resistance profile. Its use is guided by susceptibility testing of the infecting organism.