Doripenem

Doripenem is a broad-spectrum carbapenem antibiotic used to treat serious bacterial infections. It is administered intravenously. Doripenem works by inhibiting bacterial cell wall synthesis, which ultimately leads to bacterial death. It is effective against a wide range of Gram-positive and Gram-negative bacteria, including many that are resistant to other antibiotics.

The primary indications for doripenem include complicated intra-abdominal infections and complicated urinary tract infections, including pyelonephritis. It is often reserved for situations where other antibiotic options are not suitable or have proven ineffective due to the potential for resistance development. Doripenem is typically used in hospital settings under the supervision of healthcare professionals.

Like all antibiotics, doripenem can cause side effects. Common adverse effects include rash, nausea, vomiting, diarrhea, and headache. More serious side effects, though less common, can include hypersensitivity reactions, Clostridioides difficile-associated diarrhea, and neurological effects such as seizures. Doripenem should be used with caution in patients with a history of seizures or impaired renal function. The dosage of doripenem may need to be adjusted in patients with kidney problems. It is important to complete the full course of treatment as prescribed to ensure the infection is fully cleared and to minimize the risk of antibiotic resistance.