dielsalder
The Diels-Alder reaction, named after Otto Diels and Kurt Alder, is a [4+2] cycloaddition between a conjugated diene and a dienophile that forms a cyclohexene ring. Discovered in 1928, it is one of the most versatile and widely used reactions in organic synthesis.
Mechanistically, the reaction is concerted and proceeds via a cyclic transition state in which both new bonds
Regio- and stereochemistry are governed by substituents and orbital interactions. Substituents influence regioselectivity, and the endo
Dienophile activation and variants expand the scope of the reaction. Lewis acids such as AlCl3 or TiCl4
Limitations include sensitivity to temperature, solvent, and reaction conditions, and the retro-Diels-Alder reaction can occur upon