dapsonetrimethoprim

Dapsone and trimethoprim is a combination medication used primarily to treat and prevent certain bacterial infections. Dapsone, an older sulfonamide antibiotic, works by inhibiting bacterial growth, while trimethoprim, a folate antagonist, disrupts bacterial DNA synthesis. Together, they enhance antimicrobial activity and are particularly effective against susceptible strains of bacteria.

This combination is commonly prescribed for urinary tract infections caused by susceptible organisms, including *Escherichia coli* and other gram-negative bacteria. It may also be used off-label for other infections, though its use varies by region and clinical guidelines. Dapsone alone has historically been employed to treat leprosy and dermatitis herpetiformis, but its combination with trimethoprim broadens its therapeutic applications.

The medication is typically administered orally in tablet or liquid form, with dosing depending on the infection type and patient factors. Common side effects include gastrointestinal disturbances, such as nausea or diarrhea, as well as allergic reactions. More serious adverse effects, such as blood disorders or liver dysfunction, are rare but require medical attention if they occur. Patients with a history of sulfonamide hypersensitivity or glucose-6-phosphate dehydrogenase (G6PD) deficiency should use this medication with caution, as it may exacerbate these conditions.

Resistance to dapsone and trimethoprim can develop over time, emphasizing the importance of completing the full course of treatment and avoiding unnecessary use. Healthcare providers often consider alternative antibiotics if resistance is suspected or if the infection does not respond to therapy. As with all medications, individual responses may vary, and close monitoring by a healthcare professional is recommended.