dTMP

dTMP, or deoxy-thymidine monophosphate, is a nucleoside monophosphate that plays a crucial role in DNA synthesis and repair. It is one of the four deoxyribonucleoside monophosphates, along with dAMP, dGMP, and dCMP, which are the building blocks of DNA. dTMP is derived from thymidine, a pyrimidine nucleoside, through the action of thymidine kinase and deoxycytidine kinase. In the cell, dTMP is further metabolized into deoxy-thymidine triphosphate (dTTP) by the enzyme thymidylate kinase. dTTP is then incorporated into DNA during replication and repair processes. dTMP is also a substrate for thymidylate synthase, an enzyme involved in the biosynthesis of dTMP from deoxyuridine monophosphate (dUMP). The availability of dTMP is a critical factor in DNA synthesis, and its levels are regulated by feedback inhibition of thymidylate synthase by dTTP. dTMP is a component of DNA and is essential for the proper functioning of the cell. Its deficiency or alteration can lead to various genetic disorders and diseases.