cyclinCDKs
Cyclin-dependent kinases bound to cyclins, collectively referred to as cyclin-CDKs, are a family of serine/threonine kinases that regulate the progression of the eukaryotic cell cycle and other cellular processes. The catalytic activity of a CDK depends on association with a regulatory cyclin; the pairing creates an active kinase that phosphorylates a variety of substrates to drive cell cycle transitions such as G1 to S and G2 to M, as well as processes beyond division in some organisms.
Activation and regulation of cyclin-CDKs rely on several coordinated steps. Cyclin levels rise and fall during
Across eukaryotes, different cyclin-CDK partnerships govern distinct cell cycle stages. In mammals, for example, CDK4/6 pair
Dysregulation of cyclin-CDKs is a hallmark of many cancers, leading to unchecked proliferation. Consequently, CDK inhibitors