curarelike
Curarelike refers to a group of drugs known as nondepolarizing neuromuscular blocking agents. Historically derived from curare, a plant extract used by South American indigenous peoples to poison arrows, the term now describes synthetic and semi-synthetic compounds that produce skeletal muscle paralysis by blocking neuromuscular transmission without causing depolarization.
These drugs act as competitive antagonists at nicotinic acetylcholine receptors at the motor endplate, preventing acetylcholine
In clinical use, curarelike drugs facilitate airway management and provide muscle relaxation during surgery. They do
Adverse effects can include hypotension and bronchospasm, particularly with older agents that release histamine (for example,