csontizomsejtekre
Csontizomsejtekre refers to osteoclasts, which are large multinucleated cells responsible for bone resorption. These cells are crucial for bone remodeling, a continuous process where old bone tissue is broken down and replaced with new bone tissue. Osteoclasts are derived from hematopoietic stem cells, specifically from the monocyte-macrophage lineage. Their formation and activity are tightly regulated by various signaling pathways and cytokines, including RANKL, M-CSF, and OPG.
The primary function of osteoclasts is to break down the mineralized matrix of bone. They achieve this
Imbalances in osteoclast activity can lead to various bone diseases. Overactive osteoclasts contribute to conditions like