corticoids
Corticoids, or corticosteroids, are a class of steroid hormones produced by the adrenal cortex. The principal endogenous corticoids are glucocorticoids, led by cortisol, and mineralocorticoids, led by aldosterone. The term also applies to synthetic corticosteroids used as medicines. Glucocorticoids influence metabolism and the stress response, while mineralocorticoids regulate electrolyte and fluid balance.
In physiology, glucocorticoids promote glucose production and mobilization, affect fat and protein metabolism, and modulate the
Mechanistically, corticoids exert their effects by binding to intracellular receptors: the glucocorticoid receptor (GR) or the
Medically, synthetic corticosteroids are widely used to treat inflammatory and autoimmune conditions, allergies, and certain cancers.
Adverse effects are dose- and duration-dependent and include hyperglycemia, osteoporosis, hypertension, infection risk, weight gain, and