comprimés

Comprimés, or tablets, are solid pharmaceutical dosage forms formed by compressing active ingredients with excipients into a single cohesive unit. Excipients include binders to hold the tablet together, fillers to add mass, disintegrants to aid breakup, lubricants to ease production, and coatings or colorants for protection and identification.

They come in various forms, including immediate-release tablets that dissolve quickly, modified-release types that control release, enteric-coated tablets that resist stomach acid, chewable tablets, effervescent tablets, and dissolvable forms such as sublingual, buccal, orodispersible tablets.

Manufacture involves blending the active ingredient with excipients, granulation, compression into tablets with punches and dies, and often coating to improve protection, taste, or swallowability. Tablet hardness, disintegration time, and dissolution are controlled to ensure dose uniformity.

Quality requirements follow pharmacopeial standards and regulatory oversight. Tests cover content uniformity, disintegration, dissolution, hardness, friability, and stability. Packaging commonly uses blister packs or bottles with labeling, expiry dates, and storage instructions.

Administration considerations include taking tablets with water, avoiding choking hazards, and respecting age or medical restrictions. They may interact with foods or other medicines, and improper storage can reduce potency.