cisdiamminidikloroplatinaII

CisdiamminedikloroplatinaII, commonly known as cisplatin, is a platinum-based chemotherapy drug. It is a coordination complex with the chemical formula PtCl2(NH3)2. Cisplatin functions by binding to DNA within cancer cells, forming cross-links that inhibit DNA replication and transcription, ultimately leading to cell death. It is administered intravenously. Cisplatin is a widely used treatment for various types of cancer, including testicular, ovarian, bladder, lung, and head and neck cancers. Its discovery and development marked a significant advancement in cancer treatment. Despite its efficacy, cisplatin can cause a range of side effects. Common side effects include nausea, vomiting, kidney damage (nephrotoxicity), hearing loss (ototoxicity), and nerve damage (neuropathy). These side effects are often managed with supportive care and dose adjustments. Research continues to explore methods to improve cisplatin's therapeutic index and reduce its toxicity.