chromatinbyggs
Chromatinbyggs (from chromatin and byggs, Swedish for “builds”) is a term used to describe the process of chromatin assembly and organization within the cell nucleus. It encompasses the deposition of histones onto DNA to form nucleosomes, the incorporation of histone variants, and the subsequent higher-order packing that compacts chromatin while permitting regulated access to genetic information.
Key players are histone chaperones such as CAF-1, ASF1, and HIRA, and ATP-dependent chromatin remodelers such
Chromatinbyggs is regulated by histone post-translational modifications (acetylation, methylation, phosphorylation) and by DNA methylation, which influence
Proper chromatinbyggs is essential for genome stability and normal development. Dysregulation can contribute to developmental disorders