centrosomin
Centrosomin is a conserved protein primarily found in Drosophila melanogaster (fruit flies) and other insects, where it plays a critical role in centrosome function and spindle assembly during cell division. It belongs to a family of proteins associated with centrosome maturation, microtubule organization, and mitotic spindle formation. Centrosomin is a key component of the pericentriolar material (PCM), the amorphous matrix surrounding centrioles within the centrosome.
Structurally, centrosomin features specific domains that facilitate its localization and interactions within the centrosome, including coiled-coil
Genetic studies have shown that loss or mutation of the centrosomin gene results in abnormal spindle formation,
Research on centrosomin has provided broader insights into centrosome biology, cell cycle regulation, and the mechanisms
In summary, centrosomin is a vital centrosomal protein that orchestrates microtubule organization and spindle assembly, ensuring