Home

capsaicininduced

Capsaicininduced refers to effects that arise from exposure to capsaicin, the vanilloid compound found in chili peppers. In physiology and pharmacology, capsaicininduced responses are studied to understand nociception and pain modulation.

Capsaicin acts primarily by binding to the TRPV1 receptor on small-diameter sensory neurons. Activation causes an

Capsaicininduced effects are exploited therapeutically with topical formulations (for example, capsaicin creams and high-concentration patches) that

Safety: Capsaicin can irritate skin and mucous membranes; contact with eyes or broken skin should be avoided.

influx
of
calcium
and
sodium,
leading
to
neuronal
depolarization,
release
of
neuropeptides
such
as
substance
P
and
calcitonin
gene-related
peptide,
and
a
burning
or
painful
sensation.
Repeated
exposure
to
capsaicin
can
cause
desensitization
of
sensory
fibers
and
depletion
of
substance
P,
which
underlies
its
use
in
certain
topical
analgesics
and
neuropathic
pain
treatments.
provide
analgesia
after
an
initial
burning
period.
In
research,
capsaicin-induced
activation
of
nociceptors
is
used
to
model
pain
and
to
study
mechanisms
of
sensitization
and
desensitization.
Capsaicin
is
also
a
component
of
irritants
such
as
pepper
sprays,
where
capsaicin-induced
airway
and
eye
irritation
are
the
primary
effects.
Severe
reactions
are
uncommon
but
may
occur
in
sensitive
individuals,
and
high-dose
exposures
should
be
avoided
outside
of
medical
supervision.