cGMPt

cGMPt, or cyclic guanosine monophosphate, thiophosphate, is a sulfur-containing analog of cyclic guanosine monophosphate (cGMP). This modification makes cGMPt resistant to hydrolysis by phosphodiesterases, enzymes that normally break down cGMP. This resistance allows cGMPt to persist longer in cells, potentially leading to sustained activation of cGMP-dependent signaling pathways.

cGMP itself plays a crucial role in various cellular processes, including smooth muscle relaxation, platelet aggregation inhibition, and neuronal signaling. By mimicking cGMP and resisting degradation, cGMPt can effectively activate cGMP-dependent protein kinases (PKG) and modulate ion channels. This sustained activation can have diverse physiological effects.

Researchers have explored cGMPt as a pharmacological tool to investigate cGMP signaling and as a potential therapeutic agent. Its stability makes it useful for studying the downstream effects of cGMP in different biological systems. While research is ongoing, the ability of cGMPt to prolong cGMP-mediated signals suggests potential applications in conditions where dysregulation of cGMP pathways is implicated, such as cardiovascular diseases and neurological disorders. However, its therapeutic use is still largely experimental.