cAMPsensitive
cAMPsensitive is a term used in molecular biology to describe a cellular component, typically a protein, that exhibits a change in its activity or function in response to variations in the intracellular concentration of cyclic adenosine monophosphate (cAMP). cAMP is a crucial second messenger involved in a wide array of cellular signaling pathways, mediating responses to hormones, neurotransmitters, and other extracellular stimuli. When these stimuli bind to their respective receptors on the cell surface, they can trigger the activation of adenylyl cyclase, an enzyme that synthesizes cAMP from adenosine triphosphate (ATP).
Proteins that are cAMPsensitive often possess a regulatory domain that can bind to cAMP. Upon binding, this