blebbinginä

Blebbing, also known as zeiosis, is a cellular phenomenon involving the formation of bulbous protrusions on the surface of a cell. These protrusions, termed blebs, are driven by the dynamic remodeling of the actin cytoskeleton and the underlying plasma membrane. Blebbing is a transient process, and the blebs can either retract back into the cell or be released as apoptotic bodies.

The formation of blebs is primarily regulated by the Rho kinase (ROCK) signaling pathway, which promotes the phosphorylation of myosin light chain, leading to actin-myosin contraction and membrane protrusion. This process is essential for various cellular functions, including cell migration, cell division, and programmed cell death (apoptosis). In certain pathological conditions, such as cancer and neurodegenerative diseases, abnormal blebbing can contribute to disease progression. Researchers study blebbing to understand fundamental cellular processes and to develop therapeutic strategies for diseases associated with aberrant cell behavior.