beetaoksidation
Beetaoksidation, or beta-oxidation, is the catabolic process by which fatty acids are shortened by two-carbon units to form acetyl-CoA, which then feeds energy-producing pathways such as the citric acid cycle and oxidative phosphorylation. In humans, beta-oxidation mainly occurs in mitochondria of most tissues; very long-chain and branched fatty acids are also processed in peroxisomes.
Transport and regulation are essential. Long-chain fatty acids are activated to acyl-CoA and transported into mitochondria
The cycle consists of four steps. First, acyl-CoA dehydrogenase oxidizes the fatty acyl-CoA to create a trans-double
Energy yield is substantial. Each cycle yields one FADH2 and one NADH, and one acetyl-CoA is produced
Peroxisomal beta-oxidation handles very long-chain fatty acids and branched substrates. It begins with acyl-CoA oxidase, producing