aspartaattitransaminaasin

Aspartate aminotransferase (AST), also known as aspartate transaminase or SGOT (serum glutamic oxaloacetic transaminase), is an enzyme found primarily in the liver, heart, and skeletal muscles. Its primary function is to transfer an amino group from aspartate to alpha-ketoglutarate, producing glutamate and oxaloacetate. This process is crucial for the metabolism of amino acids and the synthesis of proteins.

Elevated levels of AST in the blood can indicate tissue damage or dysfunction, particularly in the liver, heart, or muscles. This is because AST leaks into the bloodstream when these tissues are injured or stressed. Common causes of elevated AST levels include viral hepatitis, alcohol abuse, heart attacks, muscle strains, and certain medications.

AST levels are typically measured in the blood as part of a routine blood test or when evaluating symptoms such as fatigue, abdominal pain, or muscle weakness. Normal AST levels vary slightly depending on the laboratory and the specific method used for measurement, but they generally range from 10 to 40 units per liter (U/L) in adults.

Interpreting AST levels requires consideration of other factors, such as age, sex, and the presence of other liver enzymes. For example, AST levels can be elevated in the absence of liver disease in older adults or in individuals with certain genetic conditions. Therefore, a healthcare provider will consider the clinical context and other test results when evaluating AST levels.