amfoteerisille

Amfoteerisille, also known as amphotericin B, is a polyene antibiotic used to treat a variety of fungal infections. It works by binding to ergosterol, a component of fungal cell membranes, which disrupts the membrane's integrity and leads to cell death. Amfoteerisille is effective against a broad spectrum of fungi, including Candida, Aspergillus, and Cryptococcus species.

The drug is typically administered intravenously and has a relatively short half-life, requiring frequent dosing. Common side effects include fever, chills, nausea, and infusion-related reactions. More serious side effects can include kidney damage, liver toxicity, and anaphylaxis. Due to its potential for serious side effects, amfoteerisille is usually reserved for severe or life-threatening fungal infections.

Amfoteerisille was first synthesized in the 1950s and has since been a staple in antifungal therapy. It is available in various formulations, including liposomal and deoxycholate salts, which aim to improve its efficacy and reduce toxicity. Despite its effectiveness, the use of amfoteerisille is often limited by its side effects, and alternative treatments are often considered when possible. Ongoing research continues to explore new formulations and combinations to enhance its safety and efficacy.