amantadyna

Amantadine is a medication primarily known for its antiviral and antiparkinsonian properties. It was initially developed as an antiviral agent and found to be effective against the influenza A virus. Its mechanism of action as an antiviral involves blocking the M2 proton channel of the influenza A virus, which is essential for viral replication and uncoating within host cells. Due to the development of viral resistance, amantadine is no longer a recommended treatment for influenza in many regions.

In the realm of neurology, amantadine is utilized to manage symptoms of Parkinson's disease. It is thought to work by increasing the release of dopamine in the brain, a neurotransmitter that is deficient in Parkinson's patients. Additionally, it may have anticholinergic effects and NMDA receptor antagonist properties, contributing to its antiparkinsonian activity. Amantadine can help reduce tremors, rigidity, and bradykinesia (slowness of movement) associated with Parkinson's disease. It is also sometimes used to alleviate drug-induced extrapyramidal side effects, which can occur as a result of certain antipsychotic medications.

Common side effects of amantadine can include dizziness, nausea, insomnia, and confusion. It is important to use amantadine under the guidance of a healthcare professional who can determine the appropriate dosage and monitor for any adverse reactions.