aktinin1

Aktinin1 is a protein encoded by the ACTN1 gene in humans. It is a member of the spectrin superfamily and plays a crucial role as an actin-binding protein. Aktinin1 is a highly conserved protein found in a wide range of organisms, indicating its fundamental importance in cellular structure and function. It is a component of the alpha-actinin family, which also includes alpha-actinin-2, -3, and -4.

The primary function of Aktinin1 is to cross-link actin filaments, forming stable bundles that are essential for maintaining cell shape and enabling cell movement. It is particularly concentrated at focal adhesions, which are specialized structures that connect the cell's cytoskeleton to the extracellular matrix. This strategic localization allows Aktinin1 to mediate cell adhesion, migration, and signal transduction. In addition to its structural role, Aktinin1 has been implicated in various cellular processes, including muscle contraction, muscle development, and cell division. Alterations in Aktinin1 expression or function have been associated with certain diseases, though more research is needed to fully understand these connections.