acetoacetylCoAksi
Acetoacetyl-CoA is a four-carbon beta-ketoacyl-CoA compound that plays a crucial role in intermediary metabolism. It is a key intermediate in the synthesis of ketone bodies, which are produced in the liver when carbohydrate availability is low, such as during fasting or prolonged exercise. In this pathway, two molecules of acetyl-CoA are condensed to form acetoacetyl-CoA, catalyzed by the enzyme thiolase. This reaction is the first committed step in ketogenesis.
Beyond ketone body synthesis, acetoacetyl-CoA is also an important intermediate in the breakdown of fatty acids
Furthermore, acetoacetyl-CoA is involved in the biosynthesis of cholesterol and other steroids. It is a precursor