YNP1

YNP1, also known as yeast nucleoporin 1, is a protein found in yeast that plays a critical role in the formation and function of the nuclear pore complex (NPC). The NPC is a large protein structure embedded in the nuclear envelope, which acts as a selective gatekeeper for the transport of molecules between the nucleus and the cytoplasm. YNP1 is a component of the Nup100p family of nucleoporins, characterized by their repetitive phenylalanine-glycine (FG) motifs. These FG repeats are thought to be crucial for mediating the passage of macromolecules through the NPC.

Research on YNP1 has contributed to understanding the intricate assembly and regulation of the NPC. Studies have shown that YNP1 interacts with other nucleoporins and is essential for the structural integrity of the NPC. Its presence is vital for maintaining the distinct compositions of the nuclear and cytoplasmic environments, thereby ensuring proper cellular processes. Disruption of YNP1 function can lead to abnormalities in nuclear transport, affecting gene expression and overall cell viability in yeast. While YNP1 is specific to yeast, its study provides valuable insights into the conserved mechanisms of nuclear transport in eukaryotic organisms.