Verkkosidosten
Verkkosidosten, also known as network disulfides, are a specific type of chemical bond involving sulfur atoms that play a vital role in the structure and stability of various biomolecules, particularly proteins. These covalent bonds form between the thiol groups (-SH) of cysteine amino acids, leading to the creation of disulfide bridges within and between polypeptide chains. Such bonds contribute to the folding, stability, and functional conformation of proteins.
In biological systems, verkkosidosten are especially important in determining the three-dimensional structure of extracellular proteins, which
The formation of verkkosidosten occurs through an oxidation process that links two cysteine residues, often facilitated
Disulfide bonds are also relevant in the manufacturing of biopharmaceuticals, where maintaining proper disulfide bonding is
Overall, verkkosidosten play a fundamental role in the structural biology of proteins, affecting their stability, activity,