VPS35n
VPS35n is a protein that belongs to the vacuolar protein sorting 35 (VPS35) family, which plays a central role in the regulation of endosomal protein trafficking in eukaryotic cells. It has been identified in several model organisms, including mammals and plant species, and is typically encoded by a gene that is evolutionarily conserved across diverse taxa. Structurally, VPS35n is approximately 400 amino acids in length and contains several HEAT repeats that facilitate protein–protein interactions. It is a peripheral membrane protein that associates with the cytoplasmic face of endosomal membranes.
In mammals, VPS35n is a core component of the retromer complex, which is responsible for sorting transmembrane
Mutational analyses have revealed that missense variants of VPS35n are linked to neurodegenerative phenotypes in humans.
Research on VPS35n also extends to plant biology, where homologs of this protein are required for efficient
In summary, VPS35n is a versatile component of the endosomal sorting machinery, essential for maintaining cellular