VPS34IN1IN2
VPS34IN1IN2 is a protein encoded by the VPS34IN1IN2 gene in Homo sapiens. It functions as a dual inhibitor of the class III phosphatidylinositol 3‑kinase VPS34, the central catalytic subunit of the PI3K‑III complex that generates phosphatidylinositol 3‑phosphate (PI3P). By binding to VPS34 and the regulator Beclin‑1, VPS34IN1IN2 reduces PI3P production, thereby modulating autophagosome formation, endolysosomal trafficking, and vesicular transport.
The protein is composed of two distinct inhibitor domains, referred to as VPS34IN1 and VPS34IN2, which correspond
Expression of VPS34IN1IN2 is highest in neurons, liver, and skeletal muscle, suggesting a key role in the
VPS34IN1IN2 has been implicated in several disease contexts. Genome‑wide association studies have linked polymorphisms in VPS34IN1IN2
The protein is further regulated by post‑translational modifications such as phosphorylation and ubiquitination, which fine‑tune its