VLDLrester

VLDLrester is a term used in fictional or speculative discussions to denote an imagined intermediate particle in the metabolism of very-low-density lipoproteins (VLDL). The coinage blends VLDL with the notion of a remnant, suggesting a transitional form that could hypothetically arise during lipolytic processing of VLDL.

Concept and proposed characteristics: In the hypothetical model, a VLDLrester would form when VLDL particles undergo partial hydrolysis by lipoprotein lipase, retaining ApoB100 and ApoE on the surface and maintaining a triglyceride-rich core with some cholesteryl esters. Its size and density would be intermediate between VLDL and conventional remnant particles, potentially altering interactions with receptors and lipoprotein remodeling pathways.

Physiological role: As a transitional particle, the VLDLrester would bridge lipolysis and receptor-mediated clearance, possibly influencing the rate at which remnants are formed or cleared and shaping the composition of downstream LDL or remnant lipoproteins in theoretical models or simulations. In this speculative framework, it serves as a useful teaching device to illustrate the complexity of lipoprotein metabolism.

Status and usage: The concept is not a recognized entity in human physiology or clinical lipidology. It appears mainly in teaching simulations, thought experiments, or fiction to help discuss lipoprotein remodeling and the diversity of intermediary particles.

See also: VLDL, LDL, remnant lipoproteins, ApoB100, ApoE, lipoprotein lipase.