U22D4

U22D4 is a human gene located on chromosome 22, specifically at position 11.21. It is a member of the U2 small nuclear ribonucleoprotein (snRNP) family, which plays a crucial role in the splicing of pre-messenger RNA (pre-mRNA) in eukaryotic cells. The U2 snRNP complex is composed of the U2 small nuclear RNA (U2 snRNA) and several proteins, including U2AF65 and U2AF35, which are encoded by the U2AF1 and U2AF2 genes, respectively. U22D4 encodes the U2AF65 protein, which is a component of the U2 snRNP complex and is essential for the recognition and binding of the 3' splice site during pre-mRNA splicing. Mutations in the U22D4 gene have been associated with several genetic disorders, including some forms of cancer and developmental abnormalities. The U22D4 gene is highly conserved across species, suggesting its importance in fundamental biological processes.