Tumorhomöge

Tumorhomöge is a German term that translates to "tumor homogenate" in English. It refers to the cellular material derived from a tumor that has been processed to create a uniform mixture. This homogenization process typically involves disrupting the tumor tissue to release its cellular components, often through mechanical means like grinding or mincing, followed by resuspension in a suitable buffer solution. The resulting homogenate contains a variety of cellular constituents, including cells, DNA, RNA, proteins, and other molecules present within the tumor.

Tumor homogenates are utilized in various research settings, primarily in experimental oncology and cancer biology. They serve as a source of tumor-specific antigens, which can be used to study immune responses against cancer. Researchers may also employ tumor homogenates to investigate the molecular characteristics of tumors, such as gene expression patterns, protein profiles, or the presence of specific mutations. Furthermore, these homogenates can be used in preclinical studies to test the efficacy of novel therapeutic agents or to develop diagnostic tools. The consistency achieved through homogenization allows for more reproducible experimental results compared to using intact tumor tissue.