Transferin
Transferrin is a glycoprotein produced primarily by the liver that serves as the main iron-transport protein in the blood. It is a roughly 80 kDa protein with two high-affinity iron-binding sites, and it exists in iron-free form (apotransferrin) or iron-saturated form (holotransferrin). Transferrin binds ferric iron (Fe3+) and keeps it soluble for transport to tissues.
Transferrin delivers iron to cells through transferrin receptors, notably TfR1 and TfR2, which are expressed on
Transferrin is part of systemic iron homeostasis. Serum transferrin concentration provides transport capacity and is often
Disorders and clinical use: In iron deficiency, transferrin levels and TIBC typically rise, whereas transferrin saturation