Tosylaatit
Tosylaatit, known in English as tosylates, are esters formed from p-toluenesulfonic acid (Ts) and alcohols or other nucleophiles. They are widely used in organic synthesis as excellent leaving groups, because the tosylate anion is stabilized by the sulfonyl group and the aryl ring. A general representation is R-OTs, where R is an organic substituent.
Preparation of tosylaatit typically involves reacting an alcohol with p-toluenesulfonyl chloride (TsCl) in the presence of
Properties of tosylates include high stability under many conditions and strong leaving-group ability in both SN2
Applications of tosylaatit are broad in synthesis. Converting alcohols into tosylates activates them for subsequent substitution,