Tlastins
Tlastins are a class of proteins that play a crucial role in the structural integrity and elasticity of connective tissues in many organisms. They are particularly abundant in the skin, lungs, and blood vessels, where their unique properties are essential for these tissues to withstand stretching and recoil. Tlastins are characterized by their highly repetitive amino acid sequences, which contribute to their elastic nature. These repetitive regions are often rich in glycine and proline, amino acids that promote flexibility in protein chains.
The structure of tlastins is also notable for its alternating domains. Some domains are highly ordered and
Mutations in genes encoding tlastins can lead to various connective tissue disorders. These conditions often manifest