Tc99mMDP
Tc-99m MDP, or technetium-99m methylene diphosphonate, is a radiopharmaceutical used for bone scintigraphy. It consists of technetium-99m bound to methylene diphosphonate, a bone-seeking ligand that localizes to hydroxyapatite at sites of active bone remodeling.
Preparation and mechanism: Tc-99m pertechnetate is obtained from a molybdenum-99/technetium-99m generator and is reduced in a
Indications: Tc-99m MDP is used in bone scintigraphy to evaluate metastatic bone disease, osteomyelitis, fractures and
Imaging and interpretation: Following injection, planar whole-body images are typically acquired 2–4 hours later, with additional
Safety: The examination delivers a moderate radiation dose. Adverse reactions are rare. Pregnancy and lactation require
Limitations and interpretation: Tc-99m MDP uptake is influenced by perfusion, bone turnover, and renal function. Increased