TUT7
TUT7, short for terminal uridylyl transferase 7, is a human enzyme encoded by the ZCCHC7 gene. It belongs to the family of terminal uridylyl transferases, non-canonical poly(A) polymerases that add uridine residues to the 3' ends of RNA molecules. In human cells, TUT7 is predominantly cytoplasmic and commonly functions together with its paralog TUT4 to modify RNA substrates.
A central role of TUT7 is to catalyze the addition of uridines to the 3' ends of
Beyond let-7 regulation, TUT7 is implicated in RNA quality control and turnover, including the uridylation of
Clinical and biological relevance arises from let-7’s role as a tumor suppressor and regulator of differentiation;