TUT2

TUT2, also known as TRAM2, is a protein that plays a role in cellular processes. It is involved in the trafficking of proteins and lipids within the cell. TUT2 is a member of the Tut-like nucleotidyltransferase family, which are enzymes that can add nucleotides to molecules. This enzyme is particularly known for its involvement in the modification of lipids, specifically glycosylphosphatidylinositol (GPI) anchors. These anchors are important for attaching certain proteins to the cell membrane. TUT2 catalyzes the addition of GlcNAc to the GPI anchor precursor in the endoplasmic reticulum. This step is crucial for the proper maturation and function of GPI-anchored proteins. The gene encoding TUT2 is located on chromosome 17. Mutations in the TUT2 gene have been associated with certain rare genetic disorders, highlighting its importance in human health. Research continues to explore the precise mechanisms and broader roles of TUT2 in cellular biology and disease. Its function is essential for maintaining the integrity and signaling capabilities of the cell membrane.