TRDNderived

TRDNderived is a label encountered in a limited set of genomic and proteomic resources, used to indicate sequences, transcripts, or proteoforms that are derived from the TRDN gene locus. The TRDN gene encodes triadin, a membrane protein involved in the regulation of calcium release in cardiac and skeletal muscle. The term itself is not part of formal gene or protein ontologies, and its exact meaning can vary by dataset or study.

In practice, TRDNderived may refer to alternatively spliced transcripts predicted from the TRDN locus, in silico translated products, or sequence variants associated with the TRDN region. Researchers may use it to separate TRDN-related data from non-TRDN data within large omics datasets, enabling focused analyses on triadin-related biology or pathology.

Because TRDNderived is not standardized, users should consult the original documentation for a given data source to confirm the intended definition. When integrating data labeled as TRDNderived, it is advisable to map to canonical TRDN transcripts and proteins and to verify the experimental validation status of the items in question.

See also: Triadin, TRDN gene, alternative splicing, transcript variant, proteoform.