TIF2

TIF2, also known as TIFF2 or TIFF-2, is a gene that encodes a protein playing a role in the regulation of gene expression. This gene is part of the larger TIFF family, which are known to interact with transcription factors. The TIF2 protein itself is a transcriptional coactivator, meaning it helps other proteins bind to DNA and initiate or enhance the transcription of genes. It contains several protein-protein interaction domains, including a glutamine-rich activation domain and a LXXLL motif, which is commonly found in nuclear receptor coactivators.

The TIF2 protein is involved in various cellular processes, including metabolism, cell growth, and differentiation. Its activity is modulated by post-translational modifications, which can affect its stability and its ability to interact with other proteins. Dysregulation of TIF2 has been implicated in certain diseases, although its precise role in human pathology is still an active area of research. Studies have investigated its involvement in conditions such as cancer and metabolic disorders. The research on TIF2 continues to explore its specific molecular mechanisms and its potential as a therapeutic target.