TGFSMADsignalering
TGFSMADsignalering refers to the Transforming Growth Factor beta (TGF-beta) signaling pathway, a fundamental biological process involved in cell growth, differentiation, apoptosis, and immune response. This pathway is initiated when a TGF-beta ligand binds to its type II receptor on the cell surface. This binding event leads to the recruitment and phosphorylation of a type I receptor, which then phosphorylates a set of intracellular proteins known as SMADs.
There are distinct types of SMAD proteins. Receptor-regulated SMADs (R-SMADs), such as SMAD2 and SMAD3 in the
Inhibitor SMADs (I-SMADs), such as SMAD7, act as negative regulators of the pathway by preventing the phosphorylation