TAS3a

TAS3a, also known as the tubulin-associated unit 3A, is a protein encoded by the TAS3A gene in humans. It is a component of the tetratricopeptide repeat (TPR) protein family, which are known for their roles in protein-protein interactions and as scaffolds for various cellular processes. TAS3a is specifically involved in the regulation of cell division and chromosome segregation.

This protein interacts with several other key proteins involved in mitosis, including components of the spindle assembly checkpoint and proteins that regulate microtubule dynamics. Its precise function is still under investigation, but it is believed to play a crucial role in ensuring that chromosomes are correctly attached to the spindle fibers and are divided equally between daughter cells. Disruptions in TAS3a function have been linked to aneuploidy, a condition where cells have an abnormal number of chromosomes, which can lead to developmental disorders and cancer.

Research into TAS3a has primarily utilized cell culture models and genetic studies. Understanding its molecular mechanisms and interactions is an active area of scientific inquiry, with the potential to reveal new therapeutic targets for diseases associated with chromosomal instability.